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[texts]RAX and anophthalmia in humans: Evidence of brain anomalies. (Volume 18) - Abouzeid, Hana
This article is from Molecular Vision, volume 18.AbstractPurpose: To report the clinical and genetic study of two families of Egyptian origin with clinical anophthalmia. To further determine the role of the retina and anterior neural fold homeobox gene (RAX) in anophthalmia and associated cerebral malformations. Methods: Three patients with clinical anophthalmia and first-degree relatives from two consanguineous families of Egyptian origin underwent full ophthalmologic, general and neurologic ex...
Downloads: 3
[texts]Alterations in the aqueous humor proteome in patients with a glaucoma shunt device. (Volume 17) - Anshu, Arundhati
This article is from Molecular Vision, volume 17.AbstractPurpose: To investigate whether implantation of a glaucoma shunt device leads to inappropriate accumulation of plasma derived proteins in the aqueous humor. Methods: Aqueous humor samples were collected from 11 patients (study group) with a glaucoma shunt device undergoing either cataract surgery or a corneal transplant and 11 patients (control) with senile cataract undergoing routine cataract extraction...
Downloads: 4
[texts]Exclusion of pathogenic promoter region variants and identification of novel nonsense mutations in the zinc finger E-box binding homeobox 1 gene in posterior polymorphous corneal dystrophy. (Volume 19) - Bakhtiari, Pejman
This article is from Molecular Vision, volume 19.AbstractPurpose: To report the identification of five novel nonsense mutations in the zinc finger E-box binding homeobox 1 (ZEB1) gene and exclusion of promoter region mutations in individuals without ZEB1 coding region mutations in posterior polymorphous corneal dystrophy (PPCD). Methods: Slit-lamp examination and DNA collection were performed for individuals diagnosed with PPCD and, when available, affected and unaffected family members...
Downloads: 2
[texts]Morphologic evaluation of meibomian glands in chronic graft-versus-host disease using in vivo laser confocal microscopy. (Volume 17) - Ban, Yumiko
This article is from Molecular Vision, volume 17.AbstractPurpose: To evaluate the morphological changes of the meibomian glands (MGs) using in vivo laser confocal microscopy (CM) in dry eye (DE) patients with chronic graft-versus-host disease (cGVHD). Methods: Seventeen eyes from 9 patients with a diagnosis of DE associated with cGVHD (DE/cGVHD group; 6 males, 3 females; median 50.5 years) and 16 eyes of 8 hematopoietic stem cell transplantation (HSCT) recipients without DE (non-DE/non-cGVHD gro...
Downloads: 6
[texts]The admirable Lady Biddy Fane : her surprising curious adventures in strange parts & happy deliverance from pirates, battle, captivity, & other terrors : together with divers romantic & moving accidents as set forth by Benet Pengilly (her companion in misfortune & joy), & now first done into print - Barrett, Frank, 1848-
Bound in illustrated paper-covered boards
Downloads: 155
[texts]Complete mitochondrial DNA genome sequence variation of Chinese families with mutation m.3635G>A and Leber hereditary optic neuropathy. (Volume 18) - Bi, Rui
This article is from Molecular Vision, volume 18.AbstractPurpose: The majority of Leber hereditary optic neuropathy (LHON) cases are caused by one of three mitochondrial DNA (mtDNA) primary mutations (m.3460G>A, m.11778G>A, and m.14484T>C). In recent studies, we and others have shown that mutation m.3635G>A is a primary LHON mutation, particularly in Chinese. The purpose of this study was to perform a thorough analysis for the complete mtDNA genome sequence variation in Chinese patients with m.3...
Downloads: 4
[texts]Quinotrierixin inhibits proliferation of human retinal pigment epithelial cells. (Volume 19) - Chen, Chen
This article is from Molecular Vision, volume 19.AbstractPurpose: To investigate the effect of quinotrierixin, a previously reported inhibitor of X-box binding protein 1 (XBP1), on cell proliferation and viability in human retinal pigment epithelium (RPE) cells. Methods: Subconfluent human RPE cells (ARPE-19) were exposed to quinotrierixin for 16–24 h. Cell proliferation was determined with 3-(4, 5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide assay, hemocytometer counts, and CyQUANT NF...
Downloads: 1
[texts]No association of age-related maculopathy susceptibility protein 2/HtrA serine peptidase 1 or complement factor H polymorphisms with early age-related maculopathy in a Chinese cohort. (Volume 19) - Chen, Jian-Huan
This article is from Molecular Vision, volume 19.AbstractPurpose: Single nucleotide polymorphisms (SNPs) of age-related maculopathy susceptibility protein 2/HtrA serine peptidase 1 (ARMS2/HTRA1) and complement factor H (CFH) have been reported to be associated with age-related macular degeneration (AMD). The purpose of this study was to investigate the association of ARMS2/HTRA1 and CFH SNPs with early age-related maculopathy (ARM) in a Han Chinese cohort...
Downloads: 3
[texts]Inhibition of VEGF expression and corneal neovascularization by shRNA targeting HIF-1? in a mouse model of closed eye contact lens wear. (Volume 18) - Chen, Peng
This article is from Molecular Vision, volume 18.AbstractPurpose: Inappropriate contact lens (CL) use and care often lead to corneal neovascularization (corneal NV). We used mouse eyes which wore CL as the animal model to assess the reason for corneal NV with CL wear. The similar and overlapping activity of vascular endothelial growth factor (VEGF) and the potent angiogenic hypoxia-inducible factor 1α (HIF-1α) called for a study of the temporal relationship in the expression of these two autoc...
Downloads: 4
[texts]IL-17A stimulates the production of inflammatory mediators via Erk1/2, p38 MAPK, PI3K/Akt, and NF-?B pathways in ARPE-19 cells. (Volume 17) - Chen, Ying
This article is from Molecular Vision, volume 17.AbstractPurpose: To investigate the signaling pathways involved in interleukin (IL)-17A -mediated production of interleukin 8 (CXCL8), chemokine (C-C motif) ligand 2 (CCL2), and interleukin 6 (IL-6) by ARPE-19 cells, a spontaneously arisen cell line of retinal pigment epithelium (RPE). Methods: Flow cytometry analysis and western blot were used to detect the phosphorylation of extracellular signal-regulated kinases 1/2 (Erk1/2), p38 mitogen activa...
Downloads: 5
[texts]Expression profile of inflammatory cytokines in aqueous from glaucomatous eyes. (Volume 18) - Chua, Jocelyn
This article is from Molecular Vision, volume 18.AbstractPurpose: To determine the proinflammatory cytokine profile of aqueous humor from glaucomatous eyes. Methods: Aqueous humor samples were prospectively collected from 38 eyes (26 primary open angle glaucoma [POAG] and 12 primary angle closure glaucoma [PACG] eyes) of 37 medically treated glaucoma patients and 23 cataract subjects recruited in an institutional setting in this case-controlled study...
Downloads: 2
[texts]Evaluation of circulating miRNAs in wet age-related macular degeneration. (Volume 20) - Ertekin, Sevda
This article is from Molecular Vision, volume 20.AbstractPurpose: In the present study, we aimed to investigate the changes in plasma miRNA in patients with wet age-related macular degeneration. Methods: The expression profiles of 384 miRNAs in plasma from 33 patients (22 male, 11 female) who were diagnosed with wet age-related macular degeneration with fundus examination, fundus fluorescein angiography, and optical coherence tomography and 31 controls (17 male, 14 female) were evaluated using h...
Downloads: 4
[texts]Identification of proteins that interact with alpha A-crystallin using a human proteome microarray. (Volume 20) - Fan, Qi
This article is from Molecular Vision, volume 20.AbstractPurpose: To identify proteins interacting with alpha A-crystallin (CRYAA) and to investigate the potential role that these protein interactions play in the function of CRYAA using a human proteome (HuProt) microarray. Methods: The active full-length CRYAA protein corresponding to amino acids 1–173 of CRYAA was recombined. A HuProt microarray composed of 17,225 human full-length proteins with N-terminal glutathione S-transferase (GST) tag...
Downloads: 1
[texts]Identification of two novel LRP5 mutations in families with familial exudative vitreoretinopathy. (Volume 20) - Fei, Ping
This article is from Molecular Vision, volume 20.AbstractPurpose: To investigate the clinical features and disease-causing mutations in two Chinese families with familial exudative vitreoretinopathy (FEVR). Methods: Clinical data and genomic DNA were collected for patients with FEVR. The coding exons and adjacent intronic regions of FZD4, LRP5, TSPAN12, and NDP were amplified with PCR, and the resulting amplicons were analyzed with Sanger sequencing...
Downloads: 3
[texts]Sports and recreations in town and country - Gale, Frederick, 1823-1904
Bound in illustrated paper-covered boards
Keywords: Outdoor recreation
Downloads: 194
[texts]Lutein and zeaxanthin supplementation reduces H2O2-induced oxidative damage in human lens epithelial cells. (Volume 17) - Gao, Shasha
This article is from Molecular Vision, volume 17.AbstractPurpose: Epidemiological studies suggest that dietary intake of lutein and zeaxanthin is inversely related to the risk for senile cataract. The objectives of this work were to investigate the mechanisms by which these nutrients provide anti-cataract effects. We evaluated their modulation of oxidative damage in human lens epithelial cells (HLEC) and their interaction with intracellular glutathione (GSH)...
Downloads: 6
[texts]Genome-wide association study of primary open angle glaucoma risk and quantitative traits. (Volume 18) - Gibson, Jane
This article is from Molecular Vision, volume 18.AbstractPurpose: Primary open angle glaucoma (POAG) is a characteristic optic neuropathy which progresses to irreversible vision loss. Few genes have been detected that influence POAG susceptibility and other genes are therefore likely to be involved. We analyzed carefully characterized POAG cases in a genome-wide association study (GWAS). Methods: We performed a GWAS in 387 POAG cases using public control data (WTCCC2)...
Downloads: 5
[texts]sCD44 overexpression increases intraocular pressure and aqueous outflow resistance. (Volume 19) - Giovingo, Michael
This article is from Molecular Vision, volume 19.AbstractPurpose: CD44 plays major roles in multiple physiologic processes. The ectodomain concentration of the CD44 receptor, soluble CD44 (sCD44), is significantly increased in the aqueous humor of primary open-angle glaucoma (POAG). The purpose of this study was to determine if adenoviral constructs of CD44 and isolated 32-kDa sCD44 change intraocular pressure (IOP) in vivo and aqueous outflow resistance in vitro...
Downloads: 3
[texts]Evaluation of MMP2 as a candidate gene for high myopia. (Volume 19) - Gong, Bo
This article is from Molecular Vision, volume 19.AbstractPurpose: Matrix metalloproteinase 2 (MMP2) has been shown to be expressed in the human sclera, and is increased in the sclera of the eye with myopia induced by form deprivation in chicks when compared with the control eye. The purpose of this study was to examine the relationship between high myopia and MMP2 in a mainland Han Chinese population...
Downloads: 5
[texts]Altered protein conformation and lower stability of the dystrophic transforming growth factor beta-induced protein mutants. (Volume 19) - Grothe, Heather L.
This article is from Molecular Vision, volume 19.AbstractPurpose: Transforming growth factor beta-induced protein (TGFBIp) is a widely expressed extracellular matrix protein that plays roles in cell adhesion and migration, differentiation, apoptosis, bone morphogenesis, and carcinogenesis. Mutations of TGFBIp have been linked to stromal corneal dystrophies, a group of protein conformational diseases characterized by abnormal protein aggregations in the cornea...
Downloads: 2
[texts]Multiplex bead array assay of plasma cytokines in type 2 diabetes mellitus with diabetic retinopathy. (Volume 20) - Hang, Hui
This article is from Molecular Vision, volume 20.AbstractPurpose: The aim of this study was to assess the roles of plasma cytokines in diabetic retinopathy (DR) and their relationship with the severity of DR. Methods: This study included 59 diabetic patients and 19 non-diabetic controls. The plasma concentrations of endothelial growth factor (EGF), eotaxin, fibroblast growth factor 2 (FGF-2), Flt-3 ligand (Flt-3L), fractalkine, granulocyte colony-stimulating factor (G-CSF), granulocyte–macroph...
Downloads: 4
[texts]The effect of vitamin C deficiency and chronic ultraviolet-B exposure on corneal ultrastructure: a preliminary investigation. (Volume 17) - Hayes, Sally
This article is from Molecular Vision, volume 17.AbstractPurpose: In the visually debilitating condition of climatic droplet keratopathy, corneal transparency is progressively lost. Although the precise cause of the disease and the mechanism by which it progresses are not known, a lifetime exposure to high solar radiation and a vitamin C–deficient diet may be involved in its development. This study examines the effect of dietary ascorbate levels and ultraviolet (UV)-B exposure on corneal strom...
Downloads: 3
[texts]NGF promotes cell cycle progression by regulating D-type cyclins via PI3K/Akt and MAPK/Erk activation in human corneal epithelial cells. (Volume 18) - Hong, Jiaxu
This article is from Molecular Vision, volume 18.AbstractPurpose: Nerve growth factor (NGF) plays an important role in promoting the healing of corneal wounds. However, the molecular mechanism by which NGF functions is unknown. We investigated the possible effects of NGF on phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) and mitogen activated protein kinase (MAPK)/extracellular signal-regulated kinase (Erk) pathways and cell growth in human corneal epithelial cells (HCECs)...
Downloads: 3
[texts]The crucial role of collagen-binding integrins in maintaining the mechanical properties of human scleral fibroblasts-seeded collagen matrix. (Volume 17) - Hu, Shoulong
This article is from Molecular Vision, volume 17.AbstractPurpose: The aim of this study was to identify the presence of collagen-binding integrin subunits in human scleral fibroblasts (HSFs) and investigate their actual functions in maintaining the mechanical creep properties of the HSFs-seeded collagen matrix. Methods: Primary HSFs were cultured in vitro. Reverse- transcription PCR was used to detect mRNA expression of integrin α1, α2, and β1 subunits in HSFs...
Downloads: 3
[texts]A novel splicing mutation of the FRMD7 gene in a Chinese family with X-linked congenital nystagmus. (Volume 18) - Hu, Ying
This article is from Molecular Vision, volume 18.AbstractPurpose: To identify a potential pathogenic mutation in a four-generation Chinese family with X-linked congenital nystagmus (XLCN). Methods: Routine clinical examination and ophthalmic evaluation were performed on normal controls, two patients and two healthy members of the family. Genomic DNA was prepared from the peripheral blood of members of the family and from 50 normal controls...
Downloads: 3
[texts]Deletion of HIF-1α partially rescues the abnormal hyaloid vascular system in Cited2 conditional knockout mouse eyes. (Volume 18) - Huang, Tai-Qin
This article is from Molecular Vision, volume 18.AbstractPurpose: Cited2 (CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2) is a member of a new family of transcriptional modulators. Cited2 null embryos exhibit hyaloid hypercellularity consisting of aberrant vasculature in the eye. The purpose of the study is to address whether abnormal lenticular development is a primary defect of Cited2 deletion and whether deletion of hypoxia inducible factor (HIF)...
Downloads: 5
[texts]Adeno-associated virus type 8 vector-mediated expression of siRNA targeting vascular endothelial growth factor efficiently inhibits neovascularization in a murine choroidal neovascularization model. (Volume 20) - Igarashi, Tsutomu
This article is from Molecular Vision, volume 20.AbstractPurpose: To assess the feasibility of a gene therapeutic approach to treating choroidal neovascularization (CNV), we generated an adeno-associated virus type 8 vector (AAV2/8) encoding an siRNA targeting vascular endothelial growth factor (VEGF), and determined the AAV2/8 vector’s ability to inhibit angiogenesis. Methods: We initially transfected 3T3 cells expressing VEGF with the AAV2/8 plasmid vector psiRNA-VEGF using the H1 promoter a...
Downloads: 1
[texts]Significant association between insertion/deletion polymorphism of the angiotensin-convertig enzyme gene and ankylosing spondylitis. (Volume 18) - Inan?r, Ahmet
This article is from Molecular Vision, volume 18.AbstractPurpose: Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease that characteristically affects the sacroiliac joints and the spine. Also iritis and uveitis can be serious complications of AS that can damage the eye and impair vision. The exact pathogenesis of AS remains poorly understood but genetic factors play a key role in its development...
Downloads: 3
[texts]Contribution of the latent transforming growth factor-beta binding protein 2 gene to etiology of primary open angle glaucoma and pseudoexfoliation syndrome. (Volume 19) - Jelodari-Mamaghani, Sahar
This article is from Molecular Vision, volume 19.AbstractPurpose: To assess for the first time the possible contribution of latent transforming growth factor (TGF)-beta binding protein 2 (LTBP2), an extracellular matrix (ECM) protein that associates with fibrillin-1-containing microfibrils, to the etiology of primary open angle glaucoma (POAG) and pseudoexfoliation (PEX) syndrome. Mutations in LTBP2 have previously been shown to be the cause of primary congenital glaucoma (PCG) and other disorde...
Downloads: 5
[texts]?1-adrenergic receptor stimulation by agonist Compound 49b restores insulin receptor signal transduction in vivo. (Volume 20) - Jiang, Youde
This article is from Molecular Vision, volume 20.AbstractPurpose: Determine whether Compound 49b treatment ameliorates retinal changes due to the lack of β2-adrenergic receptor signaling. Methods: Using retinas from 3-month-old β2-adrenergic receptor-deficient mice, we treated mice with our novel β1-/β2-adrenergic receptor agonist, Compound 49b, to assess the effects of adrenergic agonists acting only on β1-adrenergic receptors due to the absence of β2-adrenergic receptors...
Downloads: 12
[texts]Detecting genetic variations in hereditary retinal dystrophies with next-generation sequencing technology. (Volume 20) - Jin, Xin
This article is from Molecular Vision, volume 20.AbstractPurpose: To identify pathogenic mutations responsible for retinal dystrophies (RDs) in three unrelated Chinese families. Methods: Three probands from unrelated families with RDs were recruited. Genomic DNA prepared from leukocytes was analyzed using gene chip–based next-generation sequencing (NGS) to capture and sequence all of the exons of 100 known RD-associated genes...
Downloads: 4
[texts]A new mutation in the RP1L1 gene in a patient with occult macular dystrophy associated with a depolarizing pattern of focal macular electroretinograms. (Volume 18) - Kabuto, Takenori
This article is from Molecular Vision, volume 18.AbstractPurpose: To determine whether a mutation in the RP1-like protein 1 (RP1L1) gene is present in a Japanese patient with sporadic occult macular dystrophy (OMD) and to examine the characteristics of focal macular electroretinograms (ERGs) of the patient with genetically identified OMD. Methods: An individual with OMD underwent detailed ophthalmic clinical evaluations including focal macular ERGs...
Downloads: 1
[texts]Whole-exome sequencing identifies a novel ALMS1 mutation (p.Q2051X) in two Japanese brothers with Alstr?m syndrome. (Volume 19) - Katagiri, Satoshi
This article is from Molecular Vision, volume 19.AbstractPurpose: No mutations associated with Alström syndrome (AS), a rare autosomal recessive disease, have been reported in the Japanese population. The purpose of this study was to investigate the genetic and clinical features of two brothers with AS in a consanguineous Japanese family. Methods: Whole-exome sequencing analysis was performed on two brothers with AS and their unaffected parents...
Downloads: 3
[texts]Ankyrin repeat and suppressor of cytokine signaling box containing protein-10 is associated with ubiquitin-mediated degradation pathways in trabecular meshwork cells. (Volume 19) - Keller, Kate E.
This article is from Molecular Vision, volume 19.AbstractPurpose: Ankyrin repeat and suppressor of cytokine signaling (SOCS) box containing protein-10 (ASB10) was recently identified as a gene that causes primary open-angle glaucoma. Here, we investigated endogenous ASB10 protein expression in human trabecular meshwork (HTM) cells to provide the first clues to the biologic function of this protein...
Downloads: 4
[texts]A novel forkhead box C1 gene mutation in a Korean family with Axenfeld-Rieger syndrome. (Volume 19) - Kim, Gyu-Nam
This article is from Molecular Vision, volume 19.AbstractPurpose: To report a case series of patients with novel forkhead box CI (FOXC1) mutations in a Korean family with Axenfeld-Rieger syndrome (ARS). Methods: Four members of the same family underwent complete ophthalmologic and systemic examinations and genetic analysis. Genomic DNA was isolated from peripheral blood leukocytes, and all coding exons with flanking intronic regions of the FOXC1 and pituitary homeobox 2 genes were amplified usin...
Downloads: 2
[texts]Spectrum of rhodopsin mutations in Korean patients with retinitis pigmentosa. (Volume 17) - Kim, Kwang Joong
This article is from Molecular Vision, volume 17.AbstractPurpose: To determine the spectrum and frequency of rhodopsin gene (RHO) mutations in Korean patients with retinitis pigmentosa (RP) and to characterize genotype–phenotype correlations in patients with mutations. Methods: The RHO mutations were screened by direct sequencing, and mutation prevalence was measured in patients and controls. The impact of missense mutations to RP was predicted by segregation analysis, peptide sequence alignme...
Downloads: 1
[texts]Mutation analysis of the SLC4A11 gene in Indian families with congenital hereditary endothelial dystrophy 2 and a review of the literature. (Volume 19) - Kodaganur, Srinivas Gopinath
This article is from Molecular Vision, volume 19.AbstractPurpose: Congenital hereditary endothelial dystrophy 2 (CHED2) is an autosomal recessive disorder caused by mutations in the solute carrier family 4, sodium borate transporter, member 11 (SLC4A11) gene. The purpose of this study was to identify the genetic cause of CHED2 in six Indian families and catalog all known mutations in the SLC4A11 gene...
Downloads: 3
[texts]Genetic variants of FZD4 and LRP5 genes in patients with advanced retinopathy of prematurity. (Volume 19) - Kondo, Hiroyuki
This article is from Molecular Vision, volume 19.AbstractPurpose: Retinopathy of prematurity (ROP) is a complex disease with a genetic predisposition, but little is known about its genetic background. It has a clinical resemblance to familial exudative vitreoretinopathy (FEVR), a hereditary disease characterized by defects in the development of retinal vessels. Several studies have suggested that mutations in the causative genes for FEVR may account for a proportion of advanced ROP, but conflict...
Downloads: 4
[texts]Three-dimensional architecture of collagen type VI in the human trabecular meshwork. (Volume 20) - Koudouna, Elena
This article is from Molecular Vision, volume 20.AbstractPurpose: Type VI collagen is a primary component of the extracellular matrix of many connective tissues. It can form distinct aggregates depending on tissue structure, chemical environment, and physiology. In the current study we examine the ultrastructure and mode of aggregation of type VI collagen molecules in the human trabecular meshwork...
Downloads: 5
[texts]Spatial expression of aquaporin 5 in mammalian cornea and lens, and regulation of Its localization by phosphokinase A. (Volume 18) - Kumari, S. Sindhu
This article is from Molecular Vision, volume 18.AbstractPurpose: Aquaporins (AQPs) play a significant role in the movement of water across the plasma membrane. In the eye, the cornea and lens are avascular with unique microcirculatory mechanisms to meet the metabolic demands. We have previously shown that AQP0 and AQP1 water channels participate in maintaining lens transparency and homeostasis. In the present investigation, we explored the expression and spatial distribution of AQP5 in the corn...
Downloads: 3
[texts]High-mobility group box 1 protein is implicated in advanced glycation end products-induced vascular endothelial growth factor A production in the rat retinal ganglion cell line RGC-5. (Volume 18) - Lee, Jong-Jer
This article is from Molecular Vision, volume 18.AbstractPurpose: High-mobility group box 1 protein (HMGB1) has been reported to be a potent proangiogenic factor induced by inflammatory stress. In this study, we explore the role of HMGB1 in advanced glycation end products (AGEs)–induced vascular endothelial growth factor A (VEGF-A) production in rat retinal ganglion cell line 5 (RGC-5) cells. Methods: The VEGF-A protein and mRNA levels in conditioned medium of RGC-5 cells incubated with AGE-mo...
Downloads: 4
[texts]Calcium entry mediates hyperglycemia-induced apoptosis through Ca2+/calmodulin-dependent kinase ll in retinal capillary endothelial cells. (Volume 18) - Li, Jun
This article is from Molecular Vision, volume 18.AbstractPurpose: Hyperglycemia-induced vascular cell apoptosis is a seminal early event in diabetic retinopathy. Prolonged hyperglycemia is known to increase intracellular cytosolic free calcium ([Ca2+]i) in retinal vascular endothelial cells (RECs), suggesting that [Ca2+]i is a critical trigger for microvascular degeneration. This study aims to elucidate Ca2+-dependent signaling mechanisms that mediate hyperglycemia-induced apoptosis in RECs...
Downloads: 2
[texts]An updated meta-analysis: Apolipoprotein E genotypes and risk of primary open-angle glaucoma. (Volume 20) - Liao, Rongfeng
This article is from Molecular Vision, volume 20.AbstractPurpose: To study the association of apolipoprotein E (APOE) polymorphisms and primary open-angle glaucoma (POAG). Methods: After a systematic literature search, all relevant studies evaluating the association between APOE polymorphisms and POAG were included. All statistical tests were calculated with Stata 11.0. Results: Twelve independent studies on the APOE gene (1,971 cases, 1,756 controls) and POAG were included...
Downloads: 3
[texts]Assessment of ultraviolet B-blocking effects of weekly disposable contact lenses on corneal surface in a mouse model. (Volume 19) - Lin, David Pei-Cheng
This article is from Molecular Vision, volume 19.AbstractPurpose: Weekly disposable soft contact lenses have been widely used recently, but their shield effects against ultraviolet (UV) irradiation remain to be evaluated. This study investigated the bioprotective effects of several weekly soft contact lenses against UVB irradiation on the corneal surface in a mouse model. Methods: Fifty ICR mice were randomly divided into five groups: (1) blank control, (2) exposed to UVB without contact lens pr...
Downloads: 3
[texts]Molecular analysis of the choroideremia gene related clinical findings in two families with choroideremia. (Volume 17) - Lin, Ying
This article is from Molecular Vision, volume 17.AbstractPurpose: To investigate the choroideremia (CHM) gene in two families with CHM and to characterize the related clinical features. Methods: Two families underwent complete ophthalmic examinations and three males were diagnosed with CHM. Genomic DNA was extracted from the leukocytes of peripheral blood collected from the two families and from 100 unrelated control subjects from the same population...
Downloads: 2
[texts]PAX6 analysis of one family and one sporadic patient from southern China with classic aniridia. (Volume 17) - Lin, Ying
This article is from Molecular Vision, volume 17.AbstractPurpose: To investigate the paired box gene 6 (PAX6) in three patients from southern China presenting with classic aniridia: two patients from two successive generations of one family and one sporadic patient. Methods: All the available members from two successive generations of one family and one sporadic patient underwent complete physical and ophthalmic examinations...
Downloads: 3
[texts]Ala344Pro mutation in the FGFR2 gene and related clinical findings in one Chinese family with Crouzon syndrome. (Volume 18) - Lin, Ying
This article is from Molecular Vision, volume 18.AbstractPurpose: The purpose of this study was to investigate the fibroblast growth factor receptor 2 (FGFR2) gene in three Chinese patients with Crouzon syndrome and to characterize the related clinical features. Methods: A single family underwent complete ophthalmic examinations, and three patients were diagnosed with Crouzon syndrome. Genomic DNA was extracted from leukocytes of peripheral blood collected from members of the family as well as f...
Downloads: 3
[texts]Maternal germline mosaicism of kinesin family member 21A (KIF21A) mutation causes complex phenotypes in a Chinese family with congenital fibrosis of the extraocular muscles. (Volume 20) - Liu, Gang
This article is from Molecular Vision, volume 20.AbstractPurpose: To identify the causative mutation with its possible origin in a Chinese family with congenital fibrosis of extraocular muscles type 1 (CFEOM1) and to characterize the ocular phenotypes and lesions in the corresponding intracranial nerves. Methods: Three affected siblings and their asymptomatic parents underwent comprehensive ophthalmic examinations and neuropathologic analysis involving magnetic resonance imaging (MRI)...
Downloads: 3
[texts]Epithelial phenotype in total sclerocornea. (Volume 20) - Ma, David Hui-Kang
This article is from Molecular Vision, volume 20.AbstractPurpose: To understand whether the epithelial phenotype in total sclerocornea is corneal or conjunctival in origin. Methods: Four cases of total sclerocornea (male:female = 1:3; mean age = 5.4±4.3; 1–11 years old) who received penetrating keratoplasty (PKP) at our hospital between 2008 and 2011 were included. Corneal buttons obtained during PKP were used for transmission electron microscopy (TEM) as well as immunoconfocal microscopy for...
[texts]Combining chondroitinase ABC and growth factors promotes the integration of murine retinal progenitor cells transplanted into Rho−/− mice. (Volume 17) - Ma, Jian
This article is from Molecular Vision, volume 17.AbstractPurpose: The aim of this study is to investigate the synergistic effect of chondroitinase ABC and growth factors in the integration of murine retinal progenitor cells (mRPCs) transplanted into Rho−/− mice. Methods: mRPCs from P1 green fluorescent protein-transgenic mice were isolated and expanded for transplantation. All mRPCs of 20 passages or less were transplanted into the subretinal space of B6 mice together with chondroitinase ABC...
Downloads: 3
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